Merozoite surface protein-1 genetic diversity in Plasmodium malariae and Plasmodium brasilianum from Brazil
نویسندگان
چکیده
منابع مشابه
Merozoite surface protein-1 genetic diversity in Plasmodium malariae and Plasmodium brasilianum from Brazil
BACKGROUND The merozoite surface protein 1 (MSP1) gene encodes the major surface antigen of invasive forms of the Plasmodium erythrocytic stages and is considered a candidate vaccine antigen against malaria. Due to its polymorphisms, MSP1 is also useful for strain discrimination and consists of a good genetic marker. Sequence diversity in MSP1 has been analyzed in field isolates of three human ...
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Abstract Background and Objectives: Plasmodium falciparum merozoite surface protein-1 (PfMSP-1) is a promising vaccine against malaria during its blood stages which play an important role in immunity to this disease. Polymorphic nature of this gene is a major obstacle in making an effective vaccine against malaria. In this study, the genetic diversity of Plasmodi...
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The merozoite surface protein 1 (MSP-1) gene of Plasmodium falciparum encodes a major immune target under development as a malaria vaccine. In this study, we typed MSP-1 variable regions of parasites obtained from Buenaventura, Colombia. Four MSP-1 gene types were detected corresponding to prototype and recombinant K1 and MAD20 block 4 sequences. In contrast to variability within block 4, block...
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the emergence of plasmodium vivax in dashte moghan in northwestern iran has become a major concern for iranian's health officials. knowledge of genetic make up of the p. vivax populations in this area would give us an insight into the origin of the prevalent infections and the possible routes they are introduced. this paper reports the analysis of a variable region between the two interspecies ...
متن کاملgenetic diversity block 2 of surface protein-1 in plasmodium falciparum merozoite by nested-pcr method in southeastern iran
abstract background and objectives: plasmodium falciparum merozoite surface protein-1 (pfmsp-1) is a promising vaccine against malaria during its blood stages which play an important role in immunity to this disease. polymorphic nature of this gene is a major obstacle in making an effective vaccine against malaria. in this study, the genetic diversity of plasmodium falciparum isolates was...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2015
ISSN: 1471-2334
DOI: 10.1186/s12879-015-1238-8